Pediatric Oncology Drugs

Oncology drugs are targeted to specific organs or locations in the body. Approval of new cancer drugs for pediatric patients generally occurs after their development and approval for treating adult cancers. As most drug development occurs in the industry setting, the relatively small market of pediatric oncology does not provide the financial incentives for companies to actively pursue pediatric oncology solutions. Larotrectinib is the first cancer drug to receive FDA breakthrough therapy designation for patients with a specific fusion of two genes in the cancer cell, no matter what cancer type. The research appears in The Lancet Oncology. To understand challenges in childhood cancer drug development better, how all of biomedical research is supported at the national and international levels needs to be considered. In the USA, approximately 60% of funding for biomedical research stems from the private biopharmaceutical sector.

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