Pediatric Neuro- Oncology

Pediatric Neuro-Oncology is the management of children with brain and spinal cord tumors. Pediatric brain cancers can be stubborn, and typically do not respond to traditional chemotherapy and radiation. in part because the brain is somewhat protected from medications (the blood-brain barrier), in part because surgery in the brain has to be quite refined to minimize injury to brain tissue, and in part because radiation treatment to the brain can cause injury to normal brain tissue.  To successfully manage and treat children with these tumors it takes a team of practitioners specifically focused on this area. Treatment of brain tumors in children can be very different from treatment in adults. It is currently a vibrant field of research. This is desperately needed, since brain tumors have become the number one cause of cancer-related mortality in children. The thorough understanding of the immense biological heterogeneity of childhood brain tumors is a prerequisite for targeted treatment approaches. Thus, we will continue to comprehensively investigate the entire genetic and epigenetic diversity of childhood brain tumors within and across histopathological entities. Many of these novel methods are currently being prepared for routine diagnostic applications in a clinical setting through our nationally and internationally acting molecular diagnostics programs. 

 

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