Obesity in Pediatric oncology

obesity may increase the risk of cancer are not well understood, but it is believed that the combined effects of the adipose tissue environment and the endocrine alterations that accompany it among obese people both interact to promote tumor initiation and progression. Adipose tissue also creates an inflammatory environment that enhances the ability of tumor cells to metastasize. One of the main ways in which obesity can cause cancer is by promoting chronic low-level inflammation, which can, over time, cause DNA damage that leads to cancer. Articles supporting this view were reviewed by Cerda et al.[10] There are also a number of hormonal, metabolic and other changes caused by obesity that may affect carcinogenesis. A review by Tahergorabi et al. summarizes articles indicating that obesity induces changes in angiogenesis, inflammation, interaction of proinflammatory cytokines, endocrine hormones, adipokines including leptin and adiponectin, insulin, growth factors, estrogen, progesterone and cell metabolism.

 

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